Microchip-based monolithic column for high performance liquid chromatography

Completed TRL 2 (started at 1, targeting 2)

Description

We have developed microchip based monolithic columns that can be used for liquid chromatography of small organic molecules, as well as, macromolecules such as proteins and dna. We use in situ chemistry techniques to form a porous structure inside microchannels. This technology addresses the need to perform chemical analysis with high efficiency, superior reproducibility, fast speed and better column stability - all at the same time.

Fabricate the microchannels using DDL facilities. Develop a process for in situ polymerization inside the microchannels and optimize the chemistry Perform separation of organic molecules to demonstrate device capability.

Benefits

N/A

Details

Technology area	Sensors and Instruments > In Situ Instruments and Sensors > Atomic and Molecular Species Assessment
Program	Center Independent Research & Development: GSFC IRAD (GSFC IRAD)
Lead organization	Goddard Space Flight Center, Greenbelt, MD
Start date	2011-10-01
End date	2012-09-30

Project contacts

Listed on TechPort itself — the most direct way to ask about this specific project.

Theodore D Swanson — theodore.d.swanson@nasa.gov
Mahmooda Sultana — mahmooda.sultana@nasa.gov
Jason P Dworkin — jason.p.dworkin@nasa.gov
Yun Zheng — yun.zheng-1@nasa.gov

How to get involved

This is early/mid-stage (TRL 2) — the most realistic path in is NASA SBIR/STTR, which funds small businesses and research institutions to develop technology aligned with NASA's needs (equity-free, phased funding). Check whether a current SBIR/STTR solicitation topic overlaps with this project's technology area, or contact the project directly (above) to ask.

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