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Completed TRL 2 (started at 1, targeting 2)
Construct an inexpensive NTD customized for extraction of selected disease biomarkers from urine biofluid analog. Conduct trade study of sorbent materials, needle designs, and extraction methodologies. Achieve comparable or greater extraction efficiency of biomarkers to SPME with custom NTD. Generate and analyze data of NTD extraction of target disease biomarkers and validate data against COTS SPME and NTD technologies.
Develop a versatile Needle Trap Device (NTD) to extract defined metabolome disease biomarkers from biofluids.
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