Functionalization of 3D DNA Nanomaterials and Nanoarchitectures for Space-Based Technology

Watson-Crick base parity, coupled with branched DNA subunits and sticky-ended cohesion enables programmed tessellation of DNA into three-dimensional, periodic lattices of tensegrity triangles. This proposal seeks to exploit this self-assembling, highly programmable and precise biomaterial for space-based in situ nanofabrication and technological application. The project is split into four phases: (1) the design and assembly of aperiodic tensegrity triangle lattices; (2) engineering of durability via silicification and chemical ligation for operation in harsh environments; (3) functionalization of 3D DNA lattices via click chemistry and silanization; and (4) development of strategies for in situ resource utilization and functionality testing. This research hopes to deliver a fully functional, modular, self-assembling nanotechnology that will become integral to addressing critical materials and manufacturing needs for both deep-space astronauts and general society.

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