Luminescent Module Integrating Novel Analytes: A Computational Platform for Tunable Biomolecule Detection (LUMINA)

This project aims to develop a computational platform for designing luminescent chemical biosensors tailored to detect specific biomolecules at low concentrations. The biosensors will have applications in space; such as monitoring bioproduction; detecting life signatures in extraterrestrial samples; and astronaut health. The platform will use deep learning to design and optimize sensing proteins for various analytes.

This project will develop versatile; portable biosensors for detecting biomolecules in space; benefiting NASA by enhancing in-situ monitoring of bioproducts; life signatures; and astronaut health. The innovative platform combines deep learning and physics-based models for efficient design; enabling the detection of a broad range of molecular targets with improved sensitivity and adaptability.

This is early/mid-stage (TRL 2) — the most realistic path in is NASA SBIR/STTR, which funds small businesses and research institutions to develop technology aligned with NASA's needs (equity-free, phased funding). Check whether a current SBIR/STTR solicitation topic overlaps with this project's technology area, or contact the project directly (above) to ask.

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