A Crew Health Integrated Medical Exploration Response Agent (CHIMERA) platform for optimized healthcare performance

The Crew Health Integrated Medical Exploration Response Agent (CHIMERA) platform is an integrated exploration system (Medical-501) that minimizes resource costs (Medical-201) and maximizes benefit (Medical-701) through a network of Bayesian and statistical inference models (Medical-101). The primary objective of this Phase II work is to build upon previous work on an Autonomous Medical Response Agent (AMRA) and Phase I work on an Integrated Clinical Ensemble (ICE) to build, test, and deploy a platform that synthesizes networks of Bayesian and statistical models with an AI Coordinator, a shared Data lake, an insights generator and a multi-crew user interface. CHIMERA easily combines sensor data, inference models, and mission policies to allow rapid testing and validation of clinical decision support systems (CDSS) across a wide spectrum of mission architectures. This capability allows CHIMERA to scope a bespoke CDSS for each crew and mission NASA may configure in the future. CHIMERA will be deployed as a platform during a Space Medicine Exploration Hackathon at USMA West Point testing to test its interoperable capability. CHIMERA will also be deployed as a technology demonstration of terrestrial clinical decision support at the Negentex preventive primary care clinic. The Crew Health Integrated Medical Exploration Response Agent (CHIMERA) is an integrated medical system (Medical-501) that synthesizes independent Bayesian and discrete statistical models, an AI Coordinator, shared Data Lake, and Insights generator to prioritize, schedule, and guide continuously optimized medical decision support for any future mission profile. In Phase II we will a) develop the full platform, b) validate the system with synthetic astronaut data, and  c) deploy CHIMERA as a platform during a Space Medicine Exploration hackathon at USMA West Point, and as a technology demonstration in a relevant ground environment (TRL6) as a software-as-a-service for preventive primary care with Negentex Systems Medicine LLC in Maryland. The primary objective of Phase II is to establish the benefits, and feasibility of an explainable, observable, and predictable integrated exploration system called the Crew Health Integrated Medical Exploration Response Agent (CHIMERA). 1. Develop CHIMERA Platform: Develop Independent Bayesian and Discrete Statistical Models (including all 29 HFBP DAG’s and all 2023 ISS medical manual protocols)  Develop AI Coordinator and Scheduler Develop Insight Engine in coordination with CHP-IDA Develop Intelligent API and Data Lake in coordination with CHP-IDA Develop CHIMERA Interface 2. Test CHIMERA Develop synthetic physiological, environmental, vehicle, speech, and vision data for NASA Accepted Medical Conditions In Silico simulations of CHIMERA driven by simulated physiological, environmental, vehicle, speech, and vision data for NASA Accepted Medical Conditions 3. Deploy CHIMERA US Military Academy Space Medicine Exploration Hackathon with CHIMERA and Robot Operating System (ROS) based on subset of NASA Accepted Medical Conditions Technology demonstration of CHIMERA-powered preventative care at Negentex primary care clinic        

A Crew Health Integrated Medical Exploration Response Agent (CHIMERA) is a multi modal, extensible platform that allows astronauts in space and scientists and experts in mission control to collaborate asynchronously. CHIMERA will assist NASA experts to prioritize, schedule and guide continuously optimized care with limited resources across a broad set of mission profiles and objectives on the Moon, Mars, and beyond. Military: Remote autonomous critical care is essential for warfighters in peer/near-peer combat; casualties are expected to be greater than current military health capacity. Civilian: Remote medical care is increasing. Tele-ICU and home care are  $ billion industries, CHIMERA will increase capacity to provide evidence based care globally. Preventive primary care is the future of healthcare.

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