Mid-Infrared Rapid Advanced Chiroptical Life-detection Explorer (MIRACLE)

This proposal presents the MIRACLE (Mid-Infrared Rapid Advanced Chiroptical Life-detection Explorer) instrument, crafted to deepen our understanding of molecular chirality, a fundamental aspect in astrobiology and the study of life's origins. Chirality, or molecular handedness, is a pivotal feature in biological and chemical processes, and its precise measurement is essential for exploring life's origin, evolution, and the potential for life in extraterrestrial environments. The unique enantiomeric excesses found in biomolecules is a possible life signature. MIRACLE leverages advanced mid-infrared spectroscopic techniques to map molecular chirality accurately without requiring direct sample contact or large quantities, marking a substantial shift from traditional methodologies constrained by spatial, and temporal limitations. This innovative strategy is in line with the PICASSO program's objectives of advancing miniaturizable technologies to elevate the Technology Readiness Level (TRL) for space-applicable biosensing methods. At its core, MIRACLE utilizes Vibrational Circular Dichroism spectroscopy to measure enantiomeric excess by distinguishing between the absorption of left (LCP) and right circularly polarized (RCP) light states in the mid-infrared spectrum. This region is particularly beneficial due to its non-ionizing nature and ability to identify specific biomolecular vibrational modes. The differential response of D/L-amino acids to LCP/RCP light states, due to their unique chiral structures, enables accurate enantiomeric excess assessments. MIRACLE's design includes a laser-based balanced-detection system to enhance sensitivity and utilizes structured illumination to avoid raster scanning and reduce mechanical complications, thereby improving the instrument's reliability and durability -- key factors for space exploration missions. Integral to the development of MIRACLE is the strategic implementation of terrestrial analogue testing, particularly within endolithic rock structures, which are renowned habitats for stromatolites and archaeal communities. Evaluating the system's functionality under Earth conditions that mimic extraterrestrial settings ensures its performance and dependability for space missions. This validation is vital for refining the instrument to meet space exploration challenges, raising its TRL, and affirming its alignment with mission requirements. Ultimately, the MIRACLE mission seeks to enhance the PICASSO program by introducing innovative analytical capabilities for producing chirality images, a development that could revolutionize astrobiological research. By complementing the existing suite of instruments, MIRACLE is poised to facilitate chirality imaging across various planetary exploration initiatives. This instrument is specifically engineered for the discernment of structural isomers and is optimally tailored for application on planetary and ocean world surfaces, as well as subsurfaces, targeting key mission targets such as Enceladus, Europa, and Titan. MIRACLE's adaptability allows it to function on planetary probes, measuring amino acids and other organic molecules in both solid and liquid states. MIRACLE significantly contributes to NASA's core objectives of probing life's origins and evaluating habitable environments, aligning well with the aims of the PICASSO program and expanding the array of tools for extraterrestrial research.

This is a mature technology (TRL 7+) — the realistic path in is usually NASA's Technology Transfer Program: licensing an existing NASA patent, or a Space Act Agreement to use NASA facilities/expertise directly. NASA also runs a startup licensing program with no upfront fee for companies formed to commercialize a specific NASA technology.

None of these are guaranteed paths for this specific project — TechPort itself doesn't have an "apply" button. Reaching out to the contact(s) above with a specific question is usually the fastest way to find out what's actually open.