Radiation Biomarker Detection in Breath

Proposed Goals/Objectives: Spaceflight health monitoring lacks compact, high-sensitivity tools to detect biomarkers of radiation-induced oxidative stress in real time. We aim to advance our carbon nanotube (CNT) sensor system for detecting radiation-induced volatile organic compounds (VOCs) by optimizing both hardware and software to increase sensitivity and specificity. FY26 work will enhance hardware, software, and sample handling; implement selective sensor filtering; and add calibration to enable precise VOC characterization with applicability to other medical and environmental stressors. BREATHE aligns with Ames’ Core Competencies in Intelligent/Adaptive Systems and Astrobiology & Life Sciences.

Deliverables: 1) Improved sample enrichment for stronger VOC signals. 2) Sensor selection algorithm to identify reliable sensors and correct for batch effects. 3) Redesigned gas sampling fixture with reduced headspace (40 mL to 20 mL) 4) Validated custom calibration cylinder for VOC signatures of radiation-induced oxidative stress.

This is a mature technology (TRL 7+) — the realistic path in is usually NASA's Technology Transfer Program: licensing an existing NASA patent, or a Space Act Agreement to use NASA facilities/expertise directly. NASA also runs a startup licensing program with no upfront fee for companies formed to commercialize a specific NASA technology.

None of these are guaranteed paths for this specific project — TechPort itself doesn't have an "apply" button. Reaching out to the contact(s) above with a specific question is usually the fastest way to find out what's actually open.