FY26 IRAD : Detection and Characterization of Single Mag-EC ELISAConstructs for Ultra-Low LOD Life Detection (ARIA)

Proposed Goals/Objectives: Our goal is to better understand the physics governing Mag-EC ELISA detection. Our hypothesis is that we will be able to measure individual bead constructs as they impact an electrode surface. Further, we believe that we can leverage this phenomenon by using a large amount of Mag-EC ELISA constructs to ensure capture target molecules throughout the solution and rapidly draw all the constructs to the electrode for detection. If we can successfully develop analytical and computational models to describe this detection strategy, these advances will enable future life-detection technologies on missions where sample volume is limited, and target concentration is expected to be very low.

Deliverables: (1) Develop injection manifold that that is compatible with microbead particulate and resistant to chemical cleaning procedures (2) Quantify kinetic parameters for enzymatic reaction (3) Develop analytical model relating collision frequency to magnetic field strength

This is a mature technology (TRL 7+) — the realistic path in is usually NASA's Technology Transfer Program: licensing an existing NASA patent, or a Space Act Agreement to use NASA facilities/expertise directly. NASA also runs a startup licensing program with no upfront fee for companies formed to commercialize a specific NASA technology.

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