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Completed TRL 3 (started at 1, targeting 3)
The challenge is to map and quantify 3D vascular remodeling in critically important tissues such as the astronaut and diabetic retina and mouse gastro-intestinal tract (GI) that display translational (not rotational) geometry. Innovative 3D maps of vascular patterning by VESGEN software move beyond the 2D 'branching flatland' into the vast majority of real world applications important to astronaut and terrestrial human health. VESGEN 3D will map vascular branching by dissecting these complex, fractal-based structures according to key insights derived from physiological vascular branching rules. VESGEN quantification of 3D vascular maps will support evidence-based decisions for space and terrestrial medical imaging and therapeutic development such as drug discovery.
VESGEN 3D as Innovative Research & Discovery Tool for advances in: 1) Astronaut health countermeasures for established risks such as Visual Impairments Associated with Increased Intraocular Pressure (VIIP). 2) Improved understanding for better targeting of vascular therapies for diabetic retinopathy and cancer. Grant and Project funding by NASA Life Sciences, ExMC HRP, NIH. Licensing by imaging and drug development companies. Rotational 3D geometry in more complex organs. Potential customers and Applications: NASA Space Life Sciences (ISS and beyond); ExMC HRP; Space Radiation; US National Institutes of Health; Imaging Companies (Zeiss, Optovue, Heidelberg Engineering); Drug Discovery Companies (Genentech, Pfizer)
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