Multidimensional Processing and Visual Rendering of Complex 3D Biomedical Images, Year 1

To develop and utilize advanced image analysis techniques to maximize the resolution and utility of medical imaging methods being used during spaceflight. We have utilized advanced data reduction and multidimensional imaging techniques to significantly increase the information that can be extracted from the onboard biomedical imaging systems. In years 1&2 of this IR&D, we have demonstrated the ability to track volume changes in the choroid and retinal substructure in ocular images collected on ground test subjects and ISS crewmembers. This work resulted in a revision of the on orbit OCT protocol and two inflight tests before completion of year 2. This will complete the initial infusion point bringing these technical benefits to the on orbit OCT testing and follow on clinical assessment of OCT images. In year 3, we will perform integration of ultrasound images with the OCT to enable deeper structural assessment of optic nerve head. These techniques continue to enhance the monitoring and evaluation of crew vision issues during space flight. Finally, the extension of these techniques to non-ocular images at the cellular/subcellular level will be used for structure/function assessment of immune cells.

If successful, this task will result in technical approaches that can immediately be incorporated into ongoing operations and research activity including active flight and ground research venues. The techniques and protocols developed have potential to be incorporated in to ongoing operational monitoring of flight crew ocular health. In addition, the collection of ocular images of sufficient data content can allow the testing of multiple research hypotheses using images collected onboard with the enhanced protocols. This will allow better assessment of structural changes and their role in vision syndromes, and ultimately, more thorough understanding of the phenomenon at reduced resource cost. The extension of these techniques to non-ocular images at the cellular/subcellular level will be assessed in the out years by renewal proposals. These approaches will support the use of cellular biosentinels or 3-D culture systems thorough effective analysis of structural and biological assessment at the cellular and sub-cellular level.

This is early/mid-stage (TRL 5) — the most realistic path in is NASA SBIR/STTR, which funds small businesses and research institutions to develop technology aligned with NASA's needs (equity-free, phased funding). Check whether a current SBIR/STTR solicitation topic overlaps with this project's technology area, or contact the project directly (above) to ask.

None of these are guaranteed paths for this specific project — TechPort itself doesn't have an "apply" button. Reaching out to the contact(s) above with a specific question is usually the fastest way to find out what's actually open.